*Veterinarians serving Clayton, Garner, and surrounding areas since 1986*

I have a four year old, female rabbit named
"Cinnamon" that has been my house pet
since she was two months old. She is litter
trained, and rules the roost at our place.
She has never had any problems and never
been to the veterinarian, but recently I've
noticed that her urine seems to have a
reddish color to it. What do you think is
going on? If she has a problem we
definitely want to help her, but we aren't
sure what to do.
Your questions are good ones, and judging by
the number of calls about pet rabbits I've been
receiving recently, there are lots of people who
will benefit from hearing the answers.

There are several possible explanations for red
urine in a female rabbit. The reddish
appearance of the urine may be due to blood.
Another possibility is that you are seeing the
excretion of a plant pigment called porphyrin,
usually related to diet. These two very different
problems can look very similar to the pet
owner. The way to determine if your pets red
urine is due to blood is to take your rabbit to a
veterinarian who is experienced in working with
rabbits, and ask them to analyze the urine for
evidence of red blood cells.

Because your rabbit is four years old and there
have been no drastic changes in how you care
for your pet, it is likely that this is a case of
blood and not porphyrin in the urine. Your
veterinarian will help you to determine the
source of the bleeding.

Cinnamon's age coupled with the fact that she
has never been spayed makes me suspicious
that the source of her bleeding is the uterus. I
don't mean that I think she is in heat. Rabbits
are induced ovulators, and don't experience
heat cycles the way dogs do. The most likely
cause of uterine bleeding in your rabbit is
uterine adenocarcinoma. This is the most
common cancer in female rabbits; occurring in
up to 80% of some breeds of intact female
rabbits over four years old. In many cases
these rabbits will also have hard swellings in
the mammary glands and may have clear red
fluid discharge from the nipples.

Because uterine adenocarcinoma is a
malignant tumor, you must expect it to spread
(metastasize) if not removed quickly. The
treatment of choice for most reproductive
conditions in rabbits is to spay the rabbit as
soon as possible. However, before spaying
Cinnamon will require radiographs to make
sure the cancer has not already spread to her
lungs, and bloodwork to make sure she has
the best chances under anesthesia.

Most rabbits do very well after this surgery,
and any mammary problems usually resolve in
3-4 weeks. Preventative medicine always pays
for itself. I recommend that my rabbit patients
be spayed between 6-12 months of age, and
have yearly physical exams. Unspayed rabbits
should have physical exams every six months
when over three years old. Owners following
these rules will avoid this common problem in
their pets, and catch problems early. Costs of
surgery should be roughly equivalent to the
same surgery in a cat or small dog.